--- title: Clinical Change Order Evaluation and Vendor Negotiations description: A few tips on vendor selection and CRO strategy to drive effective vendor negotiations as part of your compliant vendor management process image: https://www.triradial.com/hubfs/AdobeStock_167707174_2.jpeg --- [Skip to content](https://www.triradial.com/blog/change-order-evaluation-and-negotiation#main-content) [![TriRadialTM_BRANDLogo2025](https://www.triradial.com/hs-fs/hubfs/TriRadialTM_BRANDLogo2025.png?width=720&height=316&name=TriRadialTM_BRANDLogo2025.png "TriRadialTM_BRANDLogo2025")](http://triradial.com) - [Blog Home](https://www.triradial.com/blog) - [Contact](mailto:info@triradial.com) - [Outsourcing](https://www.triradial.com/blog/tag/outsourcing) # Clinical Change Order Evaluation and Vendor Negotiations ![](https://www.triradial.com/hubfs/AdobeStock_167707174_2.jpeg) - October 29, 2024 [Leo Dodds](https://www.triradial.com/blog/author/leo-dodds) Client Challenge Faced **A small biopharma company was expecting a large Change Order (CO) from it’s primary CRO on a Phase IIB global clinical program that was experiencing delays. The company had limited means by which to evaluate the CO, given a mix of performance issues and COVID-related delays in study start-up and recruitment, as well as cost overruns due to low initial estimates for investigator pass-through grants. ** **TriRadial Approach** - The TriRadial team of experienced SMEs performed a deep-dive root-cause analysis into the patient recruitment delays and cost over runs - The team benchmarked investigator grants based on the site mix and our knowledge of current international rates in this therapeutic area - Performed a cost impact analysis of increases only, to facilitate a rapid negotiation approach - Revised the budgeting methodology used by the CRO to ensure transparency and to support negotiations - Helped client prepare for negotiation and participated in actual negotiation meetings with vendor **Results** - Root cause analysis identified specific areas the needed to be addressed - Cost Impact Analysis enabled a timely review and immediately evident identification of cost changes and reconciliation - The team achieved a 33% reduction from originally proposed increases in Direct Fees - The client’s study and management team received firsthand experience leading contracting and vendor negotiation practices ### Posts by Tag - [Clinical Strategy (4)](https://www.triradial.com/blog/tag/clinical-strategy) - [Quality & Compliance (4)](https://www.triradial.com/blog/tag/quality-compliance) - [FDA (3)](https://www.triradial.com/blog/tag/fda) - [Outsourcing (3)](https://www.triradial.com/blog/tag/outsourcing) - [Quality Systems (3)](https://www.triradial.com/blog/tag/quality-systems) - [Regulatory Updates (2)](https://www.triradial.com/blog/tag/regulatory-updates) - [Clinical Trial Performance (1)](https://www.triradial.com/blog/tag/clinical-trial-performance) - [Data Integrity (1)](https://www.triradial.com/blog/tag/data-integrity) - [Inspection Readiness (1)](https://www.triradial.com/blog/tag/inspection-readiness) - [Quality Strategy (1)](https://www.triradial.com/blog/tag/quality-strategy) - [Regulatory Compliance (1)](https://www.triradial.com/blog/tag/regulatory-compliance) See all   ###### LEAVE A COMMENT ## More from the Blog [![](https://www.triradial.com/hubfs/AdobeStock_259863105_2.webp)](https://www.triradial.com/blog/considerations-for-vendor-selection-process) [Outsourcing](https://www.triradial.com/blog/tag/outsourcing) ### [Considerations for Clinical Vendor Selection Process](https://www.triradial.com/blog/considerations-for-vendor-selection-process) October 29, 2024 Client Challenge Faced [Read more](https://www.triradial.com/blog/considerations-for-vendor-selection-process) [![](https://www.triradial.com/hubfs/ClinicalTrialsEurope21_Raphael_blogimg.png)](https://www.triradial.com/blog/cte-2021-qa) [Outsourcing](https://www.triradial.com/blog/tag/outsourcing) ### [CTE 2021 Q&A](https://www.triradial.com/blog/cte-2021-qa) March 9, 2022 Raphaële Mary, one of TriRadial's Vendor Outsourcing Management experts, along with Alexandra Kemmer-Brück, Senior... [Read more](https://www.triradial.com/blog/cte-2021-qa) [![](https://www.triradial.com/hubfs/Images/Analytics%2c%20Metrics%20and%20Dashboards.jpg)](https://www.triradial.com/blog/are-you-maximizing-your-asset-value-for-out-licensing) [Clinical Strategy](https://www.triradial.com/blog/tag/clinical-strategy), [Quality Systems](https://www.triradial.com/blog/tag/quality-systems), [Data Integrity](https://www.triradial.com/blog/tag/data-integrity) ### [Are you maximizing the value of your asset for out-licensing?](https://www.triradial.com/blog/are-you-maximizing-your-asset-value-for-out-licensing) June 4, 2025 It is increasingly common for biotech companies to develop products to the point of Proof of Concept or late Phase 2... 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